Medicinal Chemistry Iii Sylllabus Syllabus PDF | B.Pharm 6th Semester | Old Syllabus

Medicinal Chemistry Iii Sylllabus syllabus for 6th Semester. This page presents the detailed syllabus content from the original Old Syllabus PDF.

About This Syllabus

Antibiotics
Historical background, Nomenclature, Stereochemistry, Structure activity
relationship, Chemical degradation classification and important products of
the following classes.

Course Syllabus

Unit – I Antibiotics

Historical background, Nomenclature, Stereochemistry, Structure activity relationship, Chemical degradation classification and important products of the following classes. β-Lactam antibiotics: Penicillin, Cepholosporins, β- Lactamase inhibitors, Monobactams Aminoglycosides: Streptomycin, Neomycin, Kanamycin Tetracyclines: Tetracycline, Oxytetracycline, Chlortetracycline, Minocycline, Doxycycline

Unit – Ii Antibiotics

Historical background, Nomenclature, Stereochemistry, Structure activity relationship, Chemical degradation classification and important products of the following classes. Macrolide: Erythromycin Clarithromycin, Azithromycin. Miscellaneous: Chloramphenicol*, Clindamycin. Prodrugs: Basic concepts and application of prodrugs design. Antimalarials: Etiology of malaria. Quinolines: SAR, Quinine sulphate, Chloroquine*, Amodiaquine, Primaquine phosphate, Pamaquine*, Quinacrine hydrochloride, Mefloquine. Biguanides and dihydro triazines: Cycloguanil pamoate, Proguanil. Miscellaneous: Pyrimethamine, Artesunete, Artemether, Atovoquone.

Unit – Iii Anti-Tubercular Agents

Synthetic anti tubercular agents: Isoniozid*, Ethionamide, Ethambutol, Pyrazinamide, Para amino salicylic acid.* Anti tubercular antibiotics: Rifampicin, Rifabutin, Cycloserine Streptomycine, Capreomycin sulphate. Urinary tract anti-infective agents Quinolones: SAR of quinolones, Nalidixic Acid,Norfloxacin, Enoxacin, Ciprofloxacin*, Ofloxacin, Lomefloxacin, Sparfloxacin, Gatifloxacin, Moxifloxacin Miscellaneous: Furazolidine, Nitrofurantoin*, Methanamine.

Antiviral agents

Amantadine hydrochloride, Rimantadine hydrochloride, Idoxuridine trifluoride, Acyclovir*, Gancyclovir, Zidovudine, Didanosine, Zalcitabine, Lamivudine, Loviride, Delavirding, Ribavirin, Saquinavir, Indinavir, Ritonavir.

Unit – Iv Antifungal Agents:

Antifungal antibiotics: Amphotericin-B, Nystatin, Natamycin, Griseofulvin. Synthetic Antifungal agents: Clotrimazole, Econazole, Butoconazole, Oxiconazole Tioconozole, Miconazole*, Ketoconazole, Terconazole, Itraconazole, Fluconazole, Naftifine hydrochloride, Tolnaftate*. Anti-protozoal Agents: Metronidazole*, Tinidazole, Ornidazole, Diloxanide, Iodoquinol, Pentamidine Isethionate, Atovaquone, Eflornithine. Anthelmintics: Diethylcarbamazine citrate*, Thiabendazole, Mebendazole*, Albendazole, Niclosamide, Oxamniquine, Praziquantal, Ivermectin. Sulphonamides and Sulfones

Historical development, chemistry, classification and SAR of Sulfonamides

Sulphamethizole, Sulfisoxazole, Sulphamethizine, Sulfacetamide*, Sulphapyridine, Sulfamethoxaole*, Sulphadiazine, Mefenide acetate, Sulfasalazine. Folate reductase inhibitors: Trimethoprim*, Cotrimoxazole. Sulfones: Dapsone*.

Unit – V Introduction To Drug Design

Various approaches used in drug design. Physicochemical parameters used in quantitative structure activity relationship (QSAR) such as partition coefficient, Hammet’s electronic parameter, Tafts steric parameter and Hansch analysis. Pharmacophore modeling and docking techniques. Combinatorial Chemistry: Concept and applications chemistry: solid phase and solution phase synthesis. of combinatorial BP607P. MEDICINAL CHEMISTRY- III (Practical) I Preparation of drugs and intermediates 1. Sulphanilamide 2 .7-Hydroxy, 4-methyl coumarin 3 .Chlorobutanol 4 .Triphenyl imidazole 5 .Tolbutamide 6 .Hexamine II Assay of drugs 1 .Isonicotinic acid hydrazide

2 .Chloroquine 3 .Metronidazole 4 .Dapsone 5 .Chlorpheniramine maleate 6 .Benzyl penicillin III Preparation of medicinally important compounds or intermediates by Microwave irradiation technique IV Drawing structures and reactions using chem draw® V Determination of physicochemical properties such as logP, clogP, MR, Molecular weight, Hydrogen bond donors and acceptors for class of drugs

course content using drug design software Drug likeliness screening (Lipinskies

RO5)

Practical Syllabus

1. Sulphanilamide

The original syllabus PDF is available below for students who want to download and refer to the complete document.