Biopharmaceutics And Pharmacolinetics Syllabus PDF | B.Pharm 6th Semester | Old Syllabus

Biopharmaceutics And Pharmacolinetics syllabus for 6th Semester. This page presents the detailed syllabus content from the original Old Syllabus PDF.

About This Syllabus

Absorption; Mechanisms of drug absorption through GIT, factors influencing
drug
absorption though GIT, absorption of drug from Non per oral extra-vascular
routes, Distribution Tissue permeability of drugs, binding of drugs, apparent,
volume
of drug distribution, plasma and tissue protein binding of drugs, factors
affecting
protein-drug binding. Kinetics of protein binding, Clinical significance of
protein
binding of drugs

Course Syllabus

Unit-I Introduction To Biopharmaceutics

Absorption; Mechanisms of drug absorption through GIT, factors influencing drug absorption though GIT, absorption of drug from Non per oral extra-vascular routes, Distribution Tissue permeability of drugs, binding of drugs, apparent, volume of drug distribution, plasma and tissue protein binding of drugs, factors affecting protein-drug binding. Kinetics of protein binding, Clinical significance of protein binding of drugs

Unit- Ii Elimination: Drug Metabolism And Basic Understanding Metabolic Pathways

renal excretion of drugs, factors affecting renal excretion of drugs, renal clearance, Non renal routes of drug excretion of drugs Bioavailability and Bioequivalence: Definition and Objectives of bioavailability, absolute and relative bioavailability, measurement of bioavailability, in-vitro drug dissolution models, in-vitro-in-vivo correlations, bioequivalence studies, methods to enhance the dissolution rates and bioavailability of poorly soluble drugs.

Unit- Iii Pharmacokinetics: Definition And Introduction To Pharmacokinetics,

Compartment models, Non compartment models, physiological models, One compartment open model. (a). Intravenous Injection (Bolus) (b). Intravenous infusion and (c) Extra vascular administrations. Pharmacokinetics parameters – KE ,t1/2,Vd,AUC,Ka, Clt and CLR- definitions methods of eliminations, understanding of their significance and Application

Unit- Iv Multicompartment Models: Two Compartment Open Model. Iv Bolus

Kinetics of multiple dosing, steady state drug levels, calculation of loading and mainetnance doses and their significance in clinical settins.

Unit- V Nonlinear Pharmacokinetics: A. Introduction, B. Factors Causing Non-

linearity. c. Michaelis-menton method of estimating parameters, Explanation with example of drugs

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