Physical Pharmaceutics I 3rd Syllabus PDF | B.Pharm 3rd Semester | Old Syllabus

Physical Pharmaceutics I 3rd syllabus for 3rd Semester. This page presents the detailed syllabus content from the original Old Syllabus PDF.

About This Syllabus

Solubility of drugs: Solubility expressions, mechanisms of solute solvent
interactions,
ideal solubility parameters, solvation & association, quantitative approach to the
factors
influencing solubility of drugs, diffusion principles in biological systems.
Solubility
of gas in liquids, solubility of liquids in liquids, (Binary solutions, ideal
solutions)
Raoult’s law, real solutions. Partially miscible liquids, Critical solution
temperature and
applications. Distribution law, its limitations and applications

Course Syllabus

Unit-I Solubility Of Drugs: Solubility Expressions, Mechanisms Of Solute Solvent

interactions, ideal solubility parameters, solvation & association, quantitative approach to the factors influencing solubility of drugs, diffusion principles in biological systems. Solubility of gas in liquids, solubility of liquids in liquids, (Binary solutions, ideal solutions) Raoult’s law, real solutions. Partially miscible liquids, Critical solution temperature and applications. Distribution law, its limitations and applications

Unit-Ii States Of Matter And Properties Of Matter: State Of Matter, Changes In The

state of matter, latent heats, vapour pressure, sublimation critical point, eutectic mixtures, gases, aerosols – inhalers, relative humidity, liquid complexes, liquid crystals, glassy states, solid crystalline, amorphous & polymorphism. Physicochemical properties of drug molecules: Refractive index, optical rotation, dielectric constant, dipole moment, dissociation constant, determinations and applications

Unit-Iii Surface And Interfacial Phenomenon: Liquid Interface, Surface & Interfacial

tensions, surface free energy, measurement of surface & interfacial tensions, spreading coefficient, adsorption at liquid interfaces, surface active agents, HLB Scale, solubilisation, detergency, adsorption at solid interface.

Unit-Iv Complexation And Protein Binding: Introduction, Classification Of

Complexation, Applications, methods of analysis, protein binding, Complexation and drug action, crystalline structures of complexes and thermodynamic treatment of stability constants.

Unit-V Ph, Buffers And Isotonic Solutions: Sorensen’S Ph Scale, Ph Determination

(electrometric and calorimetric), applications of buffers, buffer equation, buffer capacity, buffers in pharmaceutical and biological systems, buffered isotonic solutions. BP306P. PHYSICAL PHARMACEUTICS – I (Practical) 1. Determination the solubility of drug at room temperature 2. Determination of pKa value by Half Neutralization/ Henderson Hasselbalch equation. 3. Determination of Partition co- efficient of benzoic acid in benzene and water 4. Determination of Partition co- efficient of Iodine in CCl4 and water 5. Determination of % composition of NaCl in a solution using phenol-water system by CST method 6. Determination of surface tension of given liquids by drop count and drop

weight method 7. Determination of HLB number of a surfactant by saponification method 8. Determination of Freundlich and Langmuir constants using activated char coal 9. Determination of critical micellar concentration of surfactants 10. Determination of stability constant and donor acceptor ratio of PABA- Caffeine complex by solubility method 11. Determination of stability constant and donor acceptor ratio of Cupric- Glycine complex by pH titration method

Practical Syllabus

1. Determination the solubility of drug at room temperature
2. Determination of pKa value by Half Neutralization/ Henderson Hasselbalch
3. Determination of Partition co- efficient of benzoic acid in benzene and water
4. Determination of Partition co- efficient of Iodine in CCl4 and water
5. Determination of % composition of NaCl in a solution using phenol-water
6. Determination of surface tension of given liquids by drop count and drop
7. Determination of HLB number of a surfactant by saponification method
8. Determination of Freundlich and Langmuir constants using activated char
9. Determination of critical micellar concentration of surfactants
10. Determination of stability constant and donor acceptor ratio of PABA-
11. Determination of stability constant and donor acceptor ratio of Cupric-

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