What is a Suppository?
A suppository is a solid dosage form intended for insertion into a body orifice, where it melts, softens, or dissolves to release the active ingredient. Rectal suppositories are the most familiar type.
Types
- Rectal suppositories
- Vaginal suppositories, commonly called pessaries in appropriate contexts
- Urethral suppositories in specialized applications
Common Suppository Bases
- Fatty or oleaginous bases
- Water-soluble or water-miscible bases
Advantages
- Useful when oral administration is difficult.
- Can provide local therapy at the site of administration.
- May provide systemic delivery for suitable drugs.
Important Formulation Considerations
Drug solubility, base selection, melting or dissolution behavior, drug release, mechanical strength, and storage conditions are important during suppository development.
Quick Revision
Suppository = solid dosage form inserted into a body orifice that releases the drug by melting, softening, or dissolving.
FAQs
What is the most common route for suppositories?
Rectal administration is a common route for suppositories.